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There are numerous chemicals throughout the world, some of which have a dose- or exposure-related toxic effect. The effects of iatrogenic causes in particular can be better defined. It is hard to prove that in laboratories toxic substances have toxic effects in everyday life, however (e.g. workplaces). Today, the pathophysiological effects of neurotoxic agents are still unknown. This review discusses the neurotoxic effects on the nervous system of scientifically established environmental and occupational agents.