A topological refactoring design strategy yields highly stable granulopoietic proteins
oleh: Julia Skokowa, Birte Hernandez Alvarez, Murray Coles, Malte Ritter, Masoud Nasri, Jérémy Haaf, Narges Aghaallaei, Yun Xu, Perihan Mir, Ann-Christin Krahl, Katherine W. Rogers, Kateryna Maksymenko, Baubak Bajoghli, Karl Welte, Andrei N. Lupas, Patrick Müller, Mohammad ElGamacy
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Skokowa et al. reconstruct the fold of a granulopoietic cytokine, resulting in de novo, hyperstable, highly active proteins with therapeutic potential for treating several neutropenia disorders.