LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
по: Eun-Jin Bae, Dong-Kyu Kim, Changyoun Kim, Michael Mante, Anthony Adame, Edward Rockenstein, Ayse Ulusoy, Michael Klinkenberg, Ga Ram Jeong, Jae Ryul Bae, Cheolsoon Lee, He-Jin Lee, Byung-Dae Lee, Donato A. Di Monte, Eliezer Masliah, Seung-Jae Lee
| Формат: | Article |
|---|---|
| Опубликовано: | Nature Portfolio 2018-08-01 |
Описание
Mutations in LRRK2 kinase are associated with Parkinson’s disease. Here the authors show that LRRK2 modulates propagation of α-synuclein, using rodent and C. elegans models, and show that this is dependent on phosphorylation of one of its substrates, RAB35.