Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
oleh: Tian-Yu Song, Min Long, Hai-Xin Zhao, Miao-Wen Zou, Hong-Jie Fan, Yang Liu, Chen-Lu Geng, Min-Fang Song, Yu-Feng Liu, Jun-Yi Chen, Yu-Lin Yang, Wen-Rong Zhou, Da-Wei Huang, Bo Peng, Zhen-Gang Peng, Yong Cang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Dysregulation of the microRNA machinery has crucial roles in cancer development. Here the authors show that inactivation of proteins involved in microRNA-mediated gene silencing, such as ANKRD52 or AGO2, confers resistance to T cell-mediated immune response in a preclinical cancer model.