Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions
oleh: Alma Andersson, Ludvig Larsson, Linnea Stenbeck, Fredrik Salmén, Anna Ehinger, Sunny Z. Wu, Ghamdan Al-Eryani, Daniel Roden, Alex Swarbrick, Åke Borg, Jonas Frisén, Camilla Engblom, Joakim Lundeberg
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
While transcriptomics have enhanced our understanding for cancer, spatial transcriptomics enable the characterisation of cellular interactions. Here, the authors integrate single cell data with spatial information for HER2 + tumours and develop tools for the prediction of interactions between tumour-infiltrating cells.