Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials
oleh: Qingshi Meng, Liang Chen, Bohui Xiong, Beining Kang, Pengfei Zhang, Shanlong Tang, Hui Han, Wei Shen, Xiaohui Feng, Shengnan Feng, Ruqing Zhong, Xiangfang Tang, Sheng Zhang, Hongfu Zhang, Yong Zhao
| Format: | Article |
|---|---|
| Diterbitkan: | American Society for Microbiology 2021-10-01 |
Deskripsi
We found previously unknown neonatal ileum developmental potentials: specific increases in undifferentiated cells, unique enterocyte differentiation, and time dependent reduction in secretory cells. Specific transcriptional factors (TFs), ligand-receptor pairs, G protein-coupled receptors, transforming growth factor β, bone morphogenetic protein signaling pathways, and the gut mucosal microbiota are involved in this process.