IQ-Switch is a QF-based innocuous, silencing-free, and inducible gene switch system in zebrafish
oleh: Jeongkwan Hong, Jae-Geun Lee, Kyung-Cheol Sohn, Kayoung Lee, Seoee Lee, Jinyoung Lee, Jihye Hong, Dongju Choi, Yeseul Hong, Hyo Sun Jin, Dae-Kyoung Choi, Su Ui Lee, Yun Kee, Jangham Jung, Young-Ki Bae, Ran Hee Hwang, Gang Min Hur, Jeong-Soo Lee, Hyunju Ro
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Hong et al. describe a new transgene expression system, IQ-Switch, and its variants and characterize their applications in cell culture and zebrafish systems. They show that IQ-Switch system has several advantages over the previous inducible transgene expression switches, including the low toxicity, tunability of expression levels and low levels of gene silencing.