The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
oleh: Geng Liu, Wojciech Barczak, Lian Ni Lee, Amit Shrestha, Nicholas M. Provine, Gulsah Albayrak, Hong Zhu, Claire Hutchings, Paul Klenerman, Nicholas B. La Thangue
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.