mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses
oleh: Nina C. Lund, Yetunde Kayode, Melanie R. McReynolds, Deanna C. Clemmer, Hannah Hudson, Isabelle Clerc, Hee-Kyung Hong, Jason M. Brenchley, Joseph Bass, Richard T. D’Aquila, Harry E. Taylor
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
mTOR limits the activation of an inflammatory gene response in monocytes. Inhibitors of mTOR enhance NF-κB-driven transcription in LPS-stimulated monocytes while depleting NAD+ through effects on the salvage pathway.