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In recent years, logistics companies of different sizes has been considerably developed all over the country, with the intensified competitions. To stand out in the competitive market, a logistics company must improve its logistics situation, focus on the function of distribution center, reduce logistics costs for enhancing the impact of supply chain, and rapidly response to customer needs. Thus, how to better design or optimize the existing distribution route for reducing logistics costs becomes a difficult problem, and this article will do some researches on it.