BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
oleh: Min Liu, Tongyu Sun, Ni Li, Junjie Peng, Da Fu, Wei Li, Li Li, Wei-Qiang Gao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-10-01 |
Deskripsi
Dysfunctional autophagy induces inflammation that contributes to tumorigenesis. Here, the authors show that loss of BRG1 impairs autophagy and enhances reactive oxygen species production to disrupt intestinal barrier integrity, leading to spontaneous colitis and subsequent colorectal cancer development.