SpotClean adjusts for spot swapping in spatial transcriptomics data
oleh: Zijian Ni, Aman Prasad, Shuyang Chen, Richard B. Halberg, Lisa M. Arkin, Beth A. Drolet, Michael A. Newton, Christina Kendziorski
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
Spatial transcriptomics experiments profile genome-wide gene expression at localized spots across a tissue. Here, the authors identify spot swapping, an artifact where RNA expressed at one tissue spot binds probes at another, and they propose SpotClean to adjust for it.