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A rapid and efficient methodology for the synthesis of polysubstituted para-quinone methides (p-QMs) from aldehyde and 2,6-di-tert-butylphenol has been achieved in solvent-free and microwave irradiation condition within 33 min. This strategy displays the advantages including high atom economy, good functional group tolerance, and environmentally friendly operation. Keywords: Para-Quinone methides (p-QMs), Green chemistry, Microwave irradiation, Environment friendly synthesis