The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex
oleh: Zeyuan Guan, Juan Chen, Ruiwen Liu, Yanke Chen, Qiong Xing, Zhangmeng Du, Meng Cheng, Jianjian Hu, Wenhui Zhang, Wencong Mei, Beijing Wan, Qiang Wang, Jie Zhang, Peng Cheng, Huanyu Cai, Jianbo Cao, Delin Zhang, Junjie Yan, Ping Yin, Michael Hothorn, Zhu Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
The VTC complex generate eukaryotic polyphosphate (polyP). Authors here reveal how the signal-activated VTC synthesize cytosolic polyP and transport polyP across vacuolar membrane into the lumen, by using cryo-EM, in-cell NMR, and smFRET analyses.