Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex

oleh: Carolin Sailer, Fabian Offensperger, Alexandra Julier, Kai-Michael Kammer, Ryan Walker-Gray, Matthew G. Gold, Martin Scheffner, Florian Stengel

Format: Article
Diterbitkan: Nature Portfolio 2018-10-01

Deskripsi

Oncoprotein E6 facilitates the E6AP-catalyzed ubiquitination of p53. Here, the authors study the structural basis of this process by qualitative and quantitative cross-linking mass spectrometry, providing insights into E6AP-E6-p53 complex assembly and the conformational dynamics that enable p53 ubiquitination.