Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome
oleh: Luis O. Romero, Rebeca Caires, A. Kaitlyn Victor, Juanma Ramirez, Francisco J. Sierra-Valdez, Patrick Walsh, Vincent Truong, Jungsoo Lee, Ugo Mayor, Lawrence T. Reiter, Valeria Vásquez, Julio F. Cordero-Morales
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
Angelman syndrome (AS) is a neurogenetic disorder. Here, the authors found that PIEZO2 activity is reduced in sensory neurons from a mouse model of AS and used a linoleic acid-enriched diet to enhance PIEZO2 function and ameliorate AS-associated gait deficits.