Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
oleh: Selena S. Schattauer, Benjamin B. Land, Kathryn L. Reichard, Antony D. Abraham, Lauren M. Burgeno, Jamie R. Kuhar, Paul E. M. Phillips, Shao En Ong, Charles Chavkin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced receptor-Gαi association.