Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice
oleh: Keisuke Ikegami, Satoru Masubuchi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Intraocular pressure, which can cause glaucoma, is found to be affected by nocturnal sympathetic noradrenaline, which inhibits phagocytosis in trabecular meshwork cells through β1-aderenergic receptor mediated cAMP-EPAC-SHIP1 activation.