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Acne vulgaris is a common chronic inflammatory skin disease. In the present study, we reported the anti-acne vulgaris effect of the <i>Mesua ferrea</i> (<i>M. ferrea</i>) flower extract. The extract was evaluated for three anti-acne-causing bacteria properties including <i>Cutibacterium acnes</i> (<i>C. acnes</i>), <i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>). The results indicated that the <i>M. ferrea</i> flower extract could be considered as the bactericidal agent against <i>S. epidermidis</i> and <i>S. aureus</i> with MIC values of 0.78 and 6.25 mg mL⁻¹ and MBC values of 1.56 and 12.50 mg mL⁻¹ and the bacteriostatic agent against <i>C. acnes</i> with MIC and MBC values of 3.12 and 25.00 mg mL⁻¹, respectively. The extract at a concentration of 25 µg mL⁻¹ also presented potent anti-inflammatory activity with a significant decrease of nitric oxide (NO) and tumor necrosis factor (TNF)-α productions in RAW 264.7 macrophage cells stimulated by LPS. In addition, the extract showed moderate to weak anti-oxidative capacities against DPPH, ABTS, FRAP and NO assays and also showed weak anti-tyrosinase activity. <i>M. ferrea</i> flower extract may serve as the alternative natural anti-acne formulations.