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Objective To explore the effect of HOXB7 on migration, invasion and the sensitivity to cisplatin in cervical cancer CASKI cells. Methods The expression level of HOXB7 in chemotherapy sensitive tissues and chemotherapy resistant tissues was detected by immunohistochemistry and Western blot. The expression level of HOXB7 in CASKI cells and cisplatin-resistant CASKI/DDP cells was detected by immunofluorescence and Western blot. sh-HOXB7 was transfected into CASKI cells and the cell invasion and migration were analyzed by transwell analysis, the sensitivity to cisplatin was detected by CCK-8 assay and flow cytometry. Results High expression of HOXB7 was found in chemoresistant tissues and CASKI/DDP cells (P＜0.001); Silencing HOXB7 inhibited migration and invasion (P＜0.001) and increased the sensitivity to cisplatin in CASKI cells (P＜0.001). Conclusions Silencing HOXB7 inhibits metastasis and increases the sensitivity to cisplatin in cervical cancer CASKI cells.