An Improved Process for the Preparation of an ?,?-Difluorosulfonylisoxazoline Herbicide
oleh: Chantal Belie, Andrew Plant, Nick Mulholland, Matthew McLachlan, Derek McCormack, Adrian Longstaff, Tony Kozakiewicz, Andy Knee, Katharine Ingram, Myriem El Qacemi, Martin Diggelmann, Jonathan Dallimore, Anne Dalençon, Eric Clarke, Jutta Boehmer, John Williams
| Format: | Article |
|---|---|
| Diterbitkan: | Swiss Chemical Society 2014-06-01 |
Deskripsi
An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole. Subsequently, a fluoride-induced reaction led to a difluoromethyl anion equivalent, which was reacted with a sulfur electrophile leading ultimately to the key difluorosulfide moiety.