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In aquaculture, biofouling management is a difficult and expensive issue. Cuprous oxide has been commonly used to prevent fouling formation. To cheapen net management and reduce the use of copper, the industry has proposed several alternatives. Currently, polyurethane coatings are being explored and commercially implemented. With this alternative, net cleaning is done in situ, reducing the number of nets necessary to raise a batch, thus ideally reducing operational costs. This pilot study compared this new strategy to the use of cuprous oxide. The results show that nets treated with antifouling perform better and bioaccumulation of copper in fish tissues do not pose health risks to fish. Alternatives involving on-site cleaning need to improve efficiency. Although the conditions of this work are not completely comparable to commercial aquaculture conditions, the results might indicate the strengths and constrains of the solutions tested in real life.