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Objective. Multicentric glioblastoma multiforme (mGBM) is a rare entity with worse prognostic than single lesion peer and impose diagnostic and therapeutic challenges. Case presentation. We report the case of a 63-year-old man presented with left-sided palsy, paraesthesia, dizziness and dysarthria. The brain magnetic resonance imaging (MRI) showed two supratentorial contrast-enhancing lesions: first in the right thalamic region and second in the left temporal lobe. Stereotactic biopsy of the right tumour was performed, and the pathology report revealed glioblastoma multiforme (GBM) grade IV. The patient underwent radiotherapy with concomitant Temozolomide (TMZ). After MRI evaluation, which described left temporal tumour progression, the patient received 3 cycles of TMZ and Irinotecan, followed by hypo fractionated reirradiation and maintenance TMZ. Disease stabilisation was achieved and monitored for the last 11 months without neurological status worsening due to multiples therapies. Conclusion. Prolonged tumoral control and survival was obtained in a multicentric GBM patient, similar to single lesion counterpart, by using a multimodal personalized approach.