Intrinsic and TME-induced metabolism adaptations of T cells and impact on their differentiation and function

oleh: soumaya ekouidhi, soumaya ekouidhi, Muhammad Zaeem eNOMAN, Claudine eKieda, amel benammar eelgaaied, Salem eChouaib

Format: Article
Diterbitkan: Frontiers Media S.A. 2016-03-01

Deskripsi

It is well recognized that the immune system and metabolism are highly integrated. In this context, multilevel interactions between metabolic system and T lymphocyte signaling and fate exist. This review will discuss different potential cell metabolism pathways involved in shaping T lymphocyte function and differentiation. We will also provide a general framework for understanding how tumor microenvironmental metabolism, associated with hypoxic stress, interferes with T-cell priming and expansion. How T cell metabolism drives T cell–mediated immunity and how the manipulation of metabolic programming for therapeutic purposes will be also discussed.