Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
oleh: Maria I. Alvarez-Vergara, Alicia E. Rosales-Nieves, Rosana March-Diaz, Guiomar Rodriguez-Perinan, Nieves Lara-Ureña, Clara Ortega-de San Luis, Manuel A. Sanchez-Garcia, Miguel Martin-Bornez, Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Beatriz Fernandez-Gomez, Miguel A. Marchena, Andrea S. Bullones-Bolanos, Jose C. Davila, Rocio Gonzalez-Martinez, Jose L. Trillo-Contreras, Ana C. Sanchez-Hidalgo, Raquel del Toro, Francisco G. Scholl, Eloisa Herrera, Martin Trepel, Jakob Körbelin, Luis M. Escudero, Javier Villadiego, Miriam Echevarria, Fernando de Castro, Antonia Gutierrez, Alberto Rabano, Javier Vitorica, Alberto Pascual
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
Aß are extracellular deposits relevant in Alzheimer’s disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced presenilin function, a trait of AD, in endothelial cells.