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Engineering the maturation of stem cell-derived cardiomyocytes
oleh: Yi Hong, Yun Zhao, Hao Li, Yunshu Yang, Meining Chen, Xi Wang, Mingyao Luo, Mingyao Luo, Mingyao Luo, Kai Wang, Kai Wang
Format: | Article |
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Diterbitkan: | Frontiers Media S.A. 2023-03-01 |
Deskripsi
The maturation of human stem cell-derived cardiomyocytes (hSC-CMs) has been a major challenge to further expand the scope of their application. Over the past years, several strategies have been proven to facilitate the structural and functional maturation of hSC-CMs, which include but are not limited to engineering the geometry or stiffness of substrates, providing favorable extracellular matrices, applying mechanical stretch, fluidic or electrical stimulation, co-culturing with niche cells, regulating biochemical cues such as hormones and transcription factors, engineering and redirecting metabolic patterns, developing 3D cardiac constructs such as cardiac organoid or engineered heart tissue, or culturing under in vivo implantation. In this review, we summarize these maturation strategies, especially the recent advancements, and discussed their advantages as well as the pressing problems that need to be addressed in future studies.