Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements
oleh: Michelle A. E. Anderson, Estela Gonzalez, Joshua X. D. Ang, Lewis Shackleford, Katherine Nevard, Sebald A. N. Verkuijl, Matthew P. Edgington, Tim Harvey-Samuel, Luke Alphey
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to mosquito control. Here the authors use transgenic lines with germline-specific regulatory elements to express Cas9 and achieve up to 94% inheritance bias, closing the gap between A. aegyptidrives and the highly efficient drives observed in Anopheles species.