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Introduction:Diseases caused by opportunistic pathogen Candida albicans are usually treated with antifungal drugs, but treatment failure is not uncommon especially in profoundly immunocompromised hosts. The aim of this study was to compare erg gene expression profiles of Candida albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Materials and methods: In this cross- sectional study, using volume based analyses we have conducted a gene expression profiling of ERG11 gene in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata. Results: Analysis of gene expression profiles revealed the decrease of ERG11 in C. albicans treated with Thymus vulgaris extracts in combination with Mentha spicata. Incubation with Thymus vulgaris and Mentha spicata extracts alone, however, resulted in a decrease in ERG11 RNA levels less than combination. Discussion and conclusion: These data suggest a common mechanism to find the probable targets e.g., in response to ergosterol depletion in C. albicans treated with Thymus vulgaris extracts alone and in combination with Mentha spicata.