High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform
oleh: Cheng-Yong Tham, LaiFong Poon, TingDong Yan, Javier Yu Peng Koh, Muhammad Khairul Ramlee, Vania Swee Imm Teoh, Suihan Zhang, Yi Cai, Zebin Hong, Gina S. Lee, Jin Liu, Hai Wei Song, William Ying Khee Hwang, Bin Tean Teh, Patrick Tan, Lifeng Xu, Angela S. Koh, Motomi Osato, Shang Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
There exist challenges in quantifying the length of individual telomeres at single nucleotide resolution. Here the authors report a method to capture telomeres and accurately analyse their length in human cell lines and patient peripheral blood leukocyte samples using single-molecule real-time sequencing.