Direct access to pyrido/pyrrolo[2,1-b]quinazolin-9(1H)-ones through silver-mediated intramolecular alkyne hydroamination reactions
oleh: Hengshuai Wang, Shengchao Jiao, Kerong Chen, Xu Zhang, Linxiang Zhao, Dan Liu, Yu Zhou, Hong Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2015-03-01 |
Deskripsi
We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1-b]quinazolin-9(1H)-ones and pyrrolo[2,1-b]quinazolin-9(1H)-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates and produces a series of fused quinazolinone heterocycles in good to excellent yields.