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This study investigated the impact of Aloe barbadensis Miller (Aloe vera) juice with acemannan on postprandial metabolic markers, antioxidant status, inflammatory responses, and appetite in overweight/obese men following high-fat (HF) meal consumption. In a randomized crossover trial with 16 participants, four meal conditions were tested: (1) HF meal, (2) HF meal with A. vera juice (350 mL), (3) HF meal with A. vera juice plus 0.5 g acemannan, and (4) HF meal with A. vera juice plus 1 g acemannan. Enriching A. vera juice with 1 g acemannan significantly reduced postprandial serum triglycerides, and free fatty acids after the HF meal (p < 0.05). Supplementing the HF meal with A. vera juice and acemannan suppressed postprandial glucose, enhanced postprandial antioxidant capacity and reduced tumor necrosis factor-α levels at 6 h (p < 0.05). Notably, the high-concentration acemannan positively influenced appetite by increasing fullness and decreasing hunger ratings. These findings suggest that acemannan enhances A. vera juice benefits in mitigating postprandial dysmetabolism.