Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation
oleh: Xinwei Liu, Yingying Ye, Liling Zhu, Xiaoyun Xiao, Boxuan Zhou, Yuanting Gu, Hang Si, Huixin Liang, Mingzhu Liu, Jiaqian Li, Qiongchao Jiang, Jiang Li, Shubin Yu, Ruiying Ma, Shicheng Su, Jian-You Liao, Qiyi Zhao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Stromal cells in the tumour microenvironment are reported to regulate cancer stemness via biomechanical signals. Here the authors show that TAZ activated by biomechanical cues enhanced cancer stem cell properties via phase separation with Nanog.