Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells
oleh: Olga A. Krasheninina, Evgeny K. Apartsin, Elena Fuentes, Aleksandra Szulc, Maksim Ionov, Alya G. Venyaminova, Dzmitry Shcharbin, F. Javier de la Mata, Maria Bryszewska, Rafael Gόmez
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-01-01 |
Deskripsi
This paper examines the complexation of anti-cancer small interfering RNAs (siRNAs) by cationic carbosilane dendrimers, and the interaction of the formed complexes with HeLa and HL-60 cancer cells. Stepwise formation of the complexes accompanied by the evolution of their properties has been observed through the increase of the charge ratio (dendrimer/siRNA). The complexes decrease the viability of both “easy-to-transfect” cells (HeLa) and “hard-to transfect” ones (HL-60), indicating a high potential of the cationic carbosilane dendrimers for siRNA delivery into tumor cells.