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Infective Endocarditis (IE) is an uncommon but a life-threatening infectious disease. Approximately 3% to 5% of cases of streptococcal infective endocarditis is caused by Nutritionally Variant Streptococci (NVS). Granulicatella species is one of the rare causes of IE. Here, authors are reporting a case of native valve endocarditis, without any pre-existing cardiac lesions, caused by Granulicatella adiacens. The patient presented with low grade intermittent fever for three months and had pan-systolic murmur with hepatomegaly and multiple vegetations in the echocardiogram. All the blood cultures were positive for Granulicatella adiacens. The patient was successfully treated with intravenous ceftriaxone and gentamycin for six weeks.