Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
oleh: Tao Qing, Hussein Mohsen, Michal Marczyk, Yixuan Ye, Tess O’Meara, Hongyu Zhao, Jeffrey P. Townsend, Mark Gerstein, Christos Hatzis, Yuval Kluger, Lajos Pusztai
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
Germline variants that affect the expression or function of protein-coding regions of cancer genes are associated with cancer susceptibility. Here, the authors show that a larger number of germline variants are present in early-onset cancers, while acquired somatic mutations are prevalent in cancers that develop at older age.