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Background/objectives: Organophosphorus compounds are extremely predominant in terms of agricultural and commercial activities. The aim of this review study was to assess the health endpoint due to organophosphorus toxicant. Methods: This study was conducted based on databases including Web of Science, Science Direct, PubMed, Springer, and Google Scholar. Results: The result of this study showed that the severity of the symptoms, which include acute cholinergic syndrome and intermediate syndrome, depends on the dose received, the exposure duration, and the patient's health status. Conclusion: Long-term or short-term exposure to organophosphorus toxins will cause symptoms of poisoning and disruption of the nervous system sites.