A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury
oleh: Shanmugam Muruganandan, Rachel Pierce, Dian Astari Teguh, Rocio Fuente Perez, Nicole Bell, Brandon Nguyen, Katherine Hohl, Brian D. Snyder, Mark W. Grinstaff, Hannah Alberico, Dori Woods, Yiwei Kong, Corneliu Sima, Sanket Bhagat, Kailing Ho, Vicki Rosen, Laura Gamer, Andreia M. Ionescu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
The growth plate cartilage supports long bone growth. Here the authors identify FoxA2+ long term stem cells in the growth plate that are stratified with short term PTHrP+ cells, participate in production of hyaline cartilage, expand in response to trauma, and whose ablation impairs cartilage regeneration.