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Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove <i>Sonneratia apetala</i>, showed remarkable antiaging activity. However, the role of SDA in antiaging remains unclear. In this article, we studied the function of SDA in antiaging by using the animal model <i>Caenorhabditis elegans</i>. Results showed that SDA inhibited production of reactive oxygen species (ROS) by 53%, and reduced the accumulation of aging markers such as lipids and lipofuscins. Moreover, SDA also enhanced the innate immune response to <i>Pseudomonas aeruginosa</i> infection. Genetic analysis of a series of mutants showed that SDA extended the lifespan of the mutants of <i>eat-2</i> and <i>glp-1</i>. Together, this effect may be related to the enhanced resistance to oxidative stress via mitochondrial and insulin/insulin-like growth factor-1 signaling (IIS) pathways. The results of this study provided new evidence for an antiaging effect of SDA in <i>C. elegans,</i> as well as insights into the implication of antiaging activity of SDA in higher organisms.