Oxidative allylic rearrangement of cycloalkenols: Formal total synthesis of enantiomerically pure trisporic acid B
oleh: Silke Dubberke, Muhammad Abbas, Bernhard Westermann
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2011-04-01 |
Deskripsi
Enantiomerically highly enriched unsaturated β-ketoesters bearing a quaternary stereocenter can be utilized as building blocks for the synthesis of natural occurring terpenes, i. a., trisporic acid and its derivatives. An advanced building block has been synthesized in a short reaction sequence, which involves an oxidative allylic rearrangement initiated by pyridinium dichromate (PDC) as the key step.