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In an era of Anthropocene, habitat loss and species extinction due to anthropogenic factors, and the upsurge in animal exploitation force us to reconsider the “animal question” and relationships between humans and animals. All forms of animal abuse violate the subjectivity of the animals by othering them as objects who are mercilessly exploited. Purportedly influenced by the social consciousness of the moral rights of animals and the animal advocacy movement, Sara Gruen’s novel “Water for Elephants” (2006), exposes the horrible reality of animals being mistreated for entertainment in the circus industry through a fictitious description of the events in the Benzini Brothers’ Shows. The framework of this research is based on two arguments: the crucial link between human insensitivity or empathy erosion and animal abuse; and the significance of empathy, in particular, “entangled empathy”, in acknowledging animals as moral subjects, taking care of them, and creating the harmonious human-animal relationship in the novel.