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Soft tissue sarcomas (STS) represent a heterogeneous group of malignancies that are all distinguished by mesodermal differentiation, with unique clinical and pathologic characteristics. Only 1% of adult malignancies are STS, which makes them comparatively uncommon. This low incidence is further complicated by their variable presentation, behavior, and long-term outcomes. There are more than 100 distinct histologic subtypes of soft tissue tumors, the majority of which are STS, according to the fifth edition of the WHO Classification of Tumors of Soft Tissue and Bone (1). The rarity and heterogeneity of these tumors, together with the difficult management paradigm, necessitate a multidisciplinary approach involving a skilled group of radiologists, pathologists, radiation and medical oncologists, and orthopedic oncologists.