Combination of T cell-redirecting bispecific antibody ERY974 and chemotherapy reciprocally enhances efficacy against non-inflamed tumours
oleh: Yuji Sano, Yumiko Azuma, Toshiaki Tsunenari, Yoko Kayukawa, Junko Shinozuka, Etsuko Fujii, Jun Amano, Yukari Nishito, Toru Maruyama, Yasuko Kinoshita, Yuichiro Sakamoto, Ayae Yoshida, Yoko Miyazaki, Yuta Sato, Chifumi Teramoto-Seida, Takahiro Ishiguro, Takayoshi Tanaka, Takehisa Kitazawa, Mika Endo
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
T-cell redirecting bispecific antibodies have emerged as therapeutic agents to promote T-cell mediated killing of tumor cells. Here the authors show that a combination of chemotherapy and ERY974, a bispecific antibody that targets glypican-3 and CD3, facilitates T cell infiltration and promotes anti-tumor responses also in non-inflamed tumors.