Chromosome abnormalities at onset of complete remission are associated with worse outcome in patients with acute myeloid leukemia and an abnormal karyotype at diagnosis: CALGB 8461 (Alliance)
oleh: Christian Niederwieser, Deedra Nicolet, Andrew J. Carroll, Jonathan E. Kolitz, Bayard L. Powell, Jessica Kohlschmidt, Richard M. Stone, John C. Byrd, Krzysztof Mrózek, Clara D. Bloomfield
| Format: | Article |
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| Diterbitkan: | Ferrata Storti Foundation 2016-12-01 |
Deskripsi
Achievement of complete remission is essential for long-term survival of acute myeloid leukemia patients. We evaluated the prognostic significance of cytogenetics at complete remission in 258 adults with de novo acute myeloid leukemia and abnormal pre-treatment karyotypes, treated on Cancer and Leukemia Group B front-line studies, with cytogenetic data at onset of morphological complete remission. Thirty-two patients had abnormal karyotypes at time of initial complete remission. Of these, 28 had at least 1 abnormality identified pre-treatment, and 4 acute myeloid leukemia-related abnormalities not detected pre-treatment. Two hundred and twenty-six patients had normal remission karyotypes. Patients with abnormal remission karyotypes were older (P