Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes
oleh: Weiyin Zhou, Shu-Hong Lin, Sairah M. Khan, Meredith Yeager, Stephen J. Chanock, Mitchell J. Machiela
Format: | Article |
---|---|
Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Abstract Age-related male Y and female X chromosome mosaicism is commonly observed in large population-based studies. To investigate the frequency of male X chromosome mosaicism, we scanned for deviations in chromosome X genotyping array intensity data in a population-based survey of 196,219 UK Biobank men. We detected 12 (0.006%) men with mosaic chromosome X gains ≥ 2 Mb and found no evidence for mosaic chromosome X loss, a level of detection substantially lower than for autosomes or other sex chromosomes. The rarity of chromosome X mosaicism in males relative to females reflects the importance of chromosome X gene dosage for leukocyte function.