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In the title compound, C17H13ClN2O2·H2O, the dihedral angle between the quinoline ring system and the benzene ring is 13.0 (1)°. An intramolecular N—H...O hydrogen bond may influence the molecular conformation. In the crystal structure, acetamide molecules are linked to water molecules via intermolecular O—H... N and N—H...O hydrogen bonds and in turn linked into chains along [010] via O—H...O hydrogen bonds.