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<i>Clostridium perfringens</i> is one of the most important zoonotic pathogens as it can cause food poisoning in humans and necrotic enteritis in both animals and humans. Meat, especially pork and chicken meat, is considered the main vehicle for the transmission of <i>C. perfringens</i> from animals to humans. The purpose of this study was to determine the prevalence, toxinotype, and antimicrobial resistance profile of <i>C. perfringens</i> isolated from pork and chicken meat sold in Vietnam. The isolation results showed that 15/50 (30%) of pork samples and 8/50 (16%) of chicken meat samples were contaminated with <i>C. perfringens</i>. The isolates exhibited their highest resistance rate to tetracycline (21/23; 91.30%) and clindamycin (10/23; 43.48%). On the contrary, their lowest resistance rates were observed in response to imipenem (2/23; 8.70%) and cefoxitin (1/23; 4.35%). In particular, 34.78% (8/23) of <i>C. perfringens</i> isolates were identified to be multidrug-resistant strains. The results of toxin genotyping indicated that all isolates were positive for the <i>cpa</i> gene and belonged to type A.