Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
oleh: Kamal R. Abdul Azeez, Sneha Chatterjee, Channing Yu, Todd R. Golub, Frank Sobott, Jonathan M. Elkins
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
The inner centromere protein (INCENP) activates Aurora kinase B (AURKB) and Aurora kinase C. Here the authors provide insights into the activation mechanism of AURKB/C by determining the crystal structure of fully active phosphorylated human AURKC bound to the phosphorylated C-terminal IN-box section of human INCENP.