ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation
oleh: Davide Esposito, Ila Pant, Yao Shen, Rui F. Qiao, Xiaobao Yang, Yiyang Bai, Jian Jin, Poulikos I. Poulikakos, Stuart A. Aaronson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-02-01 |
Deskripsi
Crosstalk between the p53 and Hippo pathway has been reported in different physiological contexts. Here, the authors show that p53 DNA contact mutations upregulate TEAD/YAP transcription indirectly and transform cells via hyperactivation of RhoA/ROCK/actomyosin signaling.