YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells
oleh: Yuchen Bai, Carolin Gotz, Ginevra Chincarini, Zixuan Zhao, Clare Slaney, Jarryd Boath, Luc Furic, Christopher Angel, Stephen M. Jane, Wayne A. Phillips, Steven A. Stacker, Camile S. Farah, Charbel Darido
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
The understanding of molecular mechanisms in different subtypes of head and neck cancer (HNC) will define subtype-specific treatment options. Here the authors show that PI3K-phospho-YBX1 axis promotes tumour growth in basal subtype of HNC, while unphosphorylated YBX1 acts as a suppressor of metastasis in the mesenchymal subtype with inactive PI3K signalling.