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Voriconazole (VOR) hydrochloride is unequivocally converted into VOR lactates and valinates upon reaction with silver salts of organic acids. This study found that the anticandidal in vitro activity of these compounds was comparable or slightly better than that of VOR. The <i>Candida albicans</i> clinical isolate overexpressing <i>CaCDR1/CaCDR2</i> genes, highly resistant to VOR, was apparently more susceptible to VOR salts. On the other hand, the susceptibility of another <i>C. albicans</i> clinical isolate (demonstrating multidrug resistance due to the overexpression of <i>CaMDR1</i>) to VOR salts was comparable to that to VOR. Comparative studies on the influence of VOR and its salts on Rhodamine 6G efflux from susceptible and multidrug-resistant <i>C. albicans</i> cells revealed that VOR salts are poorer substrates for the CaCdr1p drug efflux pump than VOR.